The official said Weinstein would be charged with committing a criminal sex act in a 2004 encounter with Lucia Evans, a then-aspiring actress who has said the Hollywood mogul forced her to perform oral sex on him in his office.
Weinstein pleaded not guilty and paid $1 million dollars on bail. "The NYPD thanks these courageous survivors for their courage to come forward and seek justice".
Weinstein earlier turned himself in at a lower Manhattan police station around 7:25 a.m. EDT (1125 GMT).
"Any allegations of non-consensual sex are unequivocally denied by Mr. Weinstein".
The allegations against Weinstein sparked the #MeToo movement and a nationwide discussion about sexual assault and harassment, compelling women and men to come forward with their own accusations against other prominent figures.
Dozens of women continued to speak out, including Gwyneth Paltrow, Angelina Jolie, Kate Beckinsale, Cara Delevingne, Salma Hayek and Lupita N'yongo, who brought attention to the conspiracy of silence surrounding Weinstein.
Harvey Weinstein Turns Himself in to Police to Face Sex Crime Charge in NYC
Some of Weinstein's accusers, including two women leading the charge against the 66-year-old producer, Asia Argento and Rose McGowan, took to social media to voice their thoughts on Weinstein's arrest.
The statute of limitations for rape and certain other sex crimes in NY was eliminated in 2006, but not for attacks that happened prior to 2001.
"We intend to move very quickly to dismiss these charges", Brafman said.
On Megyn Kelly Today, when asked what she would like to say to Weinstein if he might be listening, McGowan said, "We got you".
While Weinstein is the subject of an active investigation in NY, he's also under investigation for alleged sex crime in Los Angeles and London. We were young women who were assaulted by Weinstein and later terrorized by his vast network of complicity.
"Mr. Weinstein's criminal attorneys Blair Berk and Benjamin Brafman have said that a fair investigation of the allegations of criminal wrongdoing will prove they are without merit", a spokesperson for Weinstein told the Los Angeles Times of the Los Angeles investigation. Investigators decided not to charge him even though there was an audiotape of Mr Weinstein accepting he had touched Ms Battilana's breasts and pledging not to do so again.
The other charge is related to an incident on March 18, 2013, where Weinstein allegedly kept a woman "physically against her will" at 569 Lexington Avenue and raped her, according to the Manhattan DA's office.More news: IL officer hailed as hero for stopping high school shooting