"Wembley was great for us last season and we are even more used to that than we are the new stadium".
The opening round of Premier League fixtures is completed by Southampton's clash with Burnley at St Mary's and Watford taking on Brighton & Hove Albion at Vicarage Road.
Wenger chose to step down at the end of last season after nearly 22 years in charge of the north London club.
And the Spaniard has been given a testing opening to Premier League management.
After our mid-March trip to United, City's remaining seven opponents include two of the newly-promoted sides and just one side who finished in the 2017/18 top six - Tottenham, who will visit the Etihad Stadium on 20 April.
Fixtures for the 2018-19 Premier League season will be announced at 09:00 BST on Thursday, 14 June.More news: Donald Trump talks about G7 post Singapore summit
The Gunners have not won the Premier League title since 2004 and they have missed out on Champions League qualification for the last two seasons running.
Premier League Tottenham Hotspur will play their first home game of the 2018/19 season at Wembley before moving to their rebuilt stadium for its first Premier League fixture against Liverpool on the weekend of September 15-16.
Oddly, for the third consecutive season, we lock horns with Arsenal and Chelsea in consecutive games.
United, who begin their season at home to Leicester City, were the only team to claim three points at the Etihad against Guardiola's champions last season, with Paul Pogba inspiring the visitors to a 3-2 victory in April having trailed 2-0 at half-time.
Manchester City are the reigning champions, with promoted sides Wolverhampton Wanderers, Fulham and Cardiff City all returning to the Premier League.
England face Tunisia in their opening game on Monday, with Panama and star-studded Belgium their other opponents in Group G.