At the tender age of 22, Asensio's future at Real Madrid and with the national team seems extremely bright.
Asensio, meanwhile, was a substitute in the first game but starred from the start against Croatia, scoring twice and setting up two more.
Marco Asensio was arguably the star of the show and scored his first global goal on 33 minutes by capitalising on some sloppy midfield play to collect the ball 25 yards out and beat Lovre Kalinic with a left-footed rocket.
Vrsaljko provided Ivan Perisic with another chance during Croatia's early barrage but Spain's own right-back came to the rescue as Dani Carvajal tracked the Inter Milan winger to make a crucial intervention 10 yards from goal. Moments later, Asensio's curling shot took a deflection off the crossbar, hitting the Croatian keeper's back and bouncing in.
How to watch Spain vs. Croatia online, TV
The UEFA Nation's League match between Spain and Croatia will be broadcast live on ESPN2 and Univision Deportes. "We needed to recuperate the feelings we had before, we've played two great games", said goalscorer Asensio, who also provided three assists. Their inclusion made Luis Enrique the first Spain coach in 16 years to name six Real Madrid players in a starting lineup, making a mockery of fears in the Spanish media when he was appointed that he would discriminate against Real players over loyalty to his former club Barcelona.
Spain have rattled in the goals against Croatia to take charge of their Nations League group.
A somewhat surprise starter given Iago Aspas' showing against England, Asensio repaid his coach with arguably the finest performance of his career.
The centre-back was consistently excellent in Russian Federation but was given a torrid time here. But Spain weren't finished, 8 minutes later, Serjio Ramos scored the 5th from a corner kick. This will be the team's first Nations League match.More news: Obama says Trump is the symptom, not the cause of division