Sane, who was voted the Premier League's best young player by his fellow professionals last season, only amassed 29 minutes of action in City's first three games of this campaign.
Guardiola said he was still keen to work with Sane, but said the likes of Silva - who made just 15 league starts last season - also deserved their chance.
"We knew Fulham could be a threat - they have been impressive already this season".
"He can play three, four, five positions but he deserves all my respect", Guardiola said.More news: Chelsea assistant coach Zola was seen bowing to Hazard after hat-trick
The former Chelsea star Schurrle was on fire again on the 30th minute when he tried to catch Ederson but the Man City keeper was alert to parry the effort behind the crossbar for a corner-kick. David Silva crashed home a shot off the underside of the bar after his namesake Bernardo had turned the ball back from the byline and Sergio Aguero's shot had deflected off Denis Odoi.
"Thank you so much Manchester City for buying that guy from Monaco!"
"We were fighting for this kind of chance, and we must be ready for the fight, we must be ready for everything we're going to find there", he said.
Jesus spurned a couple of opportunities but then did well to hold up play and set up Bernardo Silva, only for the midfielder to shoot well over.
"How we start the game, how we start the second half, it didn't make it easy for ourselves fighting for something positive. They didn't have a scoreboard when I first came - a man used to come around with a blackboard with the score on it".
But Guardiola was happy with the win and predicts that the Cottagers will take points off City's title rivals.