He was the father of the 43rd president, George W. Bush.
President George H.W. Bush, 94, passed away late Friday night.
One of his grandsons, George P Bush, says George HW Bush was the "greatest man I ever knew".
His death comes less than eight months after his wife Barbara died.
"He was 94 and survived by his five children and their spouses, 17 grandchildren, eight great-grandchildren and two siblings", the statement read.
Funeral arrangements of the veteran Republican leader will be announced soon, media reports said.
Bush Sr. served two years as Ronald Reagan's vice president before upgrading to the most powerful position in the government.
Bush was married for 73 years to the former Barbara Pierce, a woman he met in his teenage years.More news: Anthony Davis trade hint dropped by Celtics GM Danny Ainge amid rumours
-Soviet Cold War that had carried the threat of nuclear annihilation.
George Herbert Walker Bush was born on June 12, 1924 in Milton, Massachusetts into a wealthy New England political dynasty - the son of Prescott Bush, a successful banker and United States senator for CT.
His younger son, Jeb Bush, served as governor of Florida and mounted a disappointing presidential run in 2016.
"Vice President of the United States".
"Our family has had a front-row seat to the most wonderful love story", Jeb Bush said. Our hearts ache with his loss, and we, with the American people, send our prayers to the entire Bush family, as we honor the life and legacy of 41.
He was elected as the 41st President in 1988 and served a single term before losing his 1992 re-election bid to Democrat Bill Clinton.
He surprised many with his success, and by 1958 had settled in Houston as president of an offshore drilling company.
Bush was the patriarch of a political dynasty that included one son who served as president, another as a governor and a grandson who now holds statewide office in Texas.