The trade talks are the result of an agreement last month between President Trump and Chinese President Xi Jinping to stop the tit-for-tat tariff conflict between the two countries for 90 days starting on New Year's Day.
"A comprehensive deal that fundamentally changes their system - I don't think that's possible", said Christopher Adams, a former USA trade official specializing in China and now a senior adviser at the law firm Covington.
"Our sense from our discussions last week in China is that China is struggling to come up with anything on the technology transfer side, and from our standpoint that's problematic", Myron Brilliant, the chamber's head of global affairs, said. "China does not want an increase in Tariffs and feels they will do much better if they make a deal".
Trump said any deal must include China opening its market to US financial institutions, manufacturing and agriculture as well as other unspecified "businesses and industries". "Without this a deal would be unacceptable!" the president also tweeted.
Trump has vetoed multiple proposed trade deals with China, choosing to push ahead with tariffs on Chinese goods to gain leverage.
The talks were threatened to be overshadowed by Monday's indictment by US prosecutors of Meng Wanzhou, the chief financial officer of Chinese telecom giant Huawei Technologies.
"The Coming Collapse of China" author Gordon Chang discusses the trade dispute between the USA and China.More news: Taliban talks offer glimmer of hope for peace
The talks have taken place against the backdrop of Chinese telecom Huawei's prosecution by Washington, which has sparked outrage in China and threatened the negotiation process.
"China's top trade negotiators are in the United States meeting with our representatives".
The White House announced earlier this month that Trump plans to meet in late February with North Korean leader Kim Jong Un. "The talks will continue and you can not expect to solve all the issues at once", said Liu Weidong, expert in United States affairs at the Chinese Academy of Social Sciences. We're talking about they're going to buy some corn.
Chinese officials are in Washington, D.C., this week for negotiations with top USA officials as the world's top two economies seek and end their trade dispute.
China's top economic official Vice Premier Liu He is part of the delegation in the U.S. January 30 and 31.
In the spring of 2018, US Treasury Secretary Steven Mnuchin led the US delegation sent to Beijing to advance trade negotiations - but with little success.
Prior to being named US Trade Representative in May 2017, Lighthizer was a specialist in worldwide trade law for more than 30 years and is a veteran of trade negotiations with Japan in the 1980s. This could maintain the threat of USA tariffs on Chinese goods for the long term.